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In some countries, in addition to oral formulations, injection solutions such as Neurobion Injection, Neurobion Forte Injection, and Dolo Neurobion Forte injection containing acetaminophen are also available

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These cells are the primary source of the excessive ECM deposition in fibrotic lesions

These effects of Pycnogenol on joints can be explained by previous findings, showing that regular intake of Pycnogenol leads to a potent decrease of pro-inflammatory markers like NF-B and COX-enzymes, as well as a decline in the release of matrix metallopeptidase (MMP) enzymes, that are responsible for destroying cartilage in joints (71)

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